Mechanism of Action and Pharmacological Profile of Daptomycin Daptomycin exhibits a unique mechanism of action that distinguishes it from many other antibiotics. Unlike agents that inhibit cell wall synthesis or protein production directly, daptomycin disrupts the electrical integrity of bacterial cell membranes. In the presence of calcium ions, daptomycin inserts its lipid tail into the bacterial membrane, forming channels that cause membrane depolarization. This process halts essential metabolic functions, leading to rapid bacterial death. Importantly, this bactericidal activity occurs without cell rupture. Pharmacologically, daptomycin demonstrates concentration-dependent killing, meaning higher concentrations result in more effective bacterial eradication. It has a relatively long half-life, allowing for once-daily dosing in most patients. Ref - https://www.marketresearchfuture.com/reports/daptomycin-market-10081